Koning, M.M.G.

preconditioning occlusion infarct infarct size artery artery occlusion animal reperfusion group 60 min tco period ischemic ischemic preconditioning effect study reduction ischemia myocardium control heart 60 min 30 min blood infarct size limitation control group flow reduction protection segment 90 min chapter blood flow verdouw pd circulation duration epicardial infarction function 15 min endocardial baseline reperfusion period 10 min tco relation ischaemic preconditioning verdouw 10 min 60 min teo collateral blood flow change recovery collateral oxygen limitation transmural fibrillation ischaemic stimulus model pressure cardiovasc mechanism result artery occlusions ventricle channel trimetazidine length infarct area control animals 30 min rvp patient systolic kloner ra koning figure decrease energy ladca preconditioning stimulus infarcted area