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Ma, J.

(Jianguo Ma)


cancer clsplatln patient adduct cisplatin study docetaxel level platinum infusion relationship resistance igrov method sample accumulation concentration clsplatin cisplatln chapter dna adduct levels formation repair protein plasma cell lines combination tumor response schedule exposure sn 38 cell line incubation pharmacokinetic chemotherapy course blood topotecan mechanism treatment figure result phase dna-adduct stoter g toxicity experiment parameter activity cancer res difference schellen stoter inhibitor effect addition model group binding tumour measurement cytotoxicity agent carboplatln assay decrease administration cancer cell line curve cancer patients intracellular topolsomerase correlation table analysis medium verweij j ·adduct clearance