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patient dosing coumarin study warfarin trial cyp 2c therapy algorithm anticoagulation coumarin derivatives vkorc requirement pharmacogenetic derivative eu-pact randomized outcome acenocoumarol genotype-guided group loading polymorphism anticoagulant therapy dose requirements anticoagulation therapy treatment monitoring vkorc 1 genes genotype hemorrhage anticoagulant dosing algorithms report range science pharmacol university loading dose algorithm monitoring dose algorithm report van schie safety factor vkorc 1 phenprocoumon future netherland event utrecht 3 months center warfarin dose maintenance number interindividual variability genotype-guided dosing time eu-pact trial wadeliu –effectivenes blood information regimen van meegen e vkorc 1 gene design european anticoagulation response control value european pharmacogenetics cost –effectiveness initiation dosing regimen genotyping variability alcohol practice dose requirement month
1 Most Recent Publications
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Genotype-guided dosing of coumarin derivatives: the European pharmacogenetics of anticoagulant therapy (EU-PACT) trial design
(Article)
Schie, R.M.F. van Wadelius, M. Briz, M. Rosendaal, F.R. Redekop, W.K. Pirmohamed, M. Maitland-van der Zee, A-H. Kamali, F. Daly, A.K. Manolopoulos, V.G. Boer, A. de Barallon, R. Verhoef, T.I. Kirchheiner, J. Haschke-Becher, E. |
2009-10-01
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