Hinnen, P.

barrett tissue light patient porphyrin oesophagu study activity ala-pdt therapy concentration photodynamic photodynamic therapy effect cancer accumulation dysplasia pdt power index administration pbg-d adenocarcinoma chapter 5- aminolaevulinic acid aminolaevulinic esophagus enzyme hinnen plasma protoporphyrin epithelium ala administration ala ingestion mucosa laser filter protoporphyrin ix illumination ingestion wilson treatment sample ferrochelatase level interval result ppix accumulation power 5- aminolevulinic acid aminolevulinic index protein porphobilinogen time intervals figure biosynthesi tumour siersema cell death photosensitizer hillegersberg photochem model acid-induced oxygen exposure time interval gastroenterology fc activity liver wavelength biosynthetic intracellular porphobilinogen deaminase experiment acrylate photochem photobiol b photobiol damage deaminase 0.001 p