Veelen, W. van

cancer mutation medullary thyroid carcinoma expression thyroid tumor level patient 18ink calcitonin ret 2b mice protein b-catenin medullary carcinoma plasma calcitonin levels rapamycin plasma p 18ink development treatment mouse kinase phosphorylation p 18ink expression month tumour tuberous sclerosis mtorc result b-catenine mtc development oncogenic ret growth biomarker medullary thyroid cancer model analysis van veelen sclerosis tuberou pathway inhibitor b-catenine 654 lkb 1/ampk mtorc 1 receptor suppressor lkb 1 therapy study table imaging disease activation oncogenic activity ret mutations syndrome figure 1/ampk tissue netherland veelen mtc patients tsc 2 antibody utrecht tumours cell growth 12 months 654/e cdk 4 function tyrosine embryo increase transgene identi tsc 1