Winkel, A. van de

barrett patient esophagus expression esophageal receptor epithelium study adenocarcinoma level hospital bile acids control tissue dysplasia figure sample gastroenterology esophageal adenocarcinoma progression cancer pxr expression disease biopsy development mrna levels effect analysis neoplastic progression reflux table result protein fxr expression factor association pxr mrna levels allele diagnosis department n b e rotterdam pregnane x receptor barrett esophagus guggulsterone polymorphism gastroenterol endoscopic discovery columnar replication biomarker model winkel netherland reflux esophagitis staining response research university group marker population erasmus mc erasmu neoplastic metaplasia chapter cohort columnar epithelium value trust slokdarm adenocarcinoma patients pathway surveillance increase exposure kuipers ej van dekken h