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expression gata 3 gata 3 expression 2-gata cd 2-gata figure factor level development differentiation 17 cells arthritis transcription cytokine immunol protein notch il -17a thymocyte effect analysis lineage number t cells il -23 c-myc induction lymphoma dp cells wild-type t cell development selection 17 differentiation -17 production hematopoietic il -4 culture result gata 2 0.6 patient flow cytometric analysis activity notch 1 0.7 -23 0.5 interleukin receptor gata -3 target gata -2 / hsc activity control chapter presence inflammation group function stage pre-b system il -17 cd 2-gata transgene 2+/- 17 cultures mouse value embryo transgene regulator cd 19-hbtk mice tumor il -17 expression cd 5 expression 11.10 cd 2-gata mice tissue 1.5
10 Most Recent Publications
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Btk levels set the threshold for B-cell activation and negative selection of autoreactive B cells in mice
(Article)
Kil, L. Bruijn, M.J.W. de Loo, P.F. van Hendriks, R.W. Nimwegen, M. van Corneth, O.B.J. Hamburg, J.P. van Dingjan, G.M. Thaiss, F. Rimmelzwaan, G.F. Elewaut, D. Delsing, D. |
2012-04-19
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Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin-17A production
(Article)
Hamburg, J.P. van Asmawidjaja, P. Davelaar, N. Mus, A.M.C. Colin, E.M. Hazes, J.M.W. Dolhain, R.J.E.M. Lubberts, E.W. |
2011-01-01
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Reply
(Letter To Editor)
Colin, E.M. Hamburg, J.P. van Lubberts, E. |
2010-10-01
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Interleukin-23 promotes Th17 differentiation by inhibiting T-bet and FoxP3 and is required for elevation of Interleukin-22, but not Interleukin-21, in autoimmune experimental arthritis
(Article)
Mus, A.M.C. Cornelissen, F.H.J. Asmawidjaja, P. Hamburg, J.P. van Boon, L. Hendriks, R.W. Lubberts, E.W. |
2010-04-01
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Malignant transformation of Slp65-deficient pre-B cells involves disruption of the Arf-Mdm2-p53 tumor suppressor pathway
(Article)
Ta, T.B.V. Bruijn, M.J.W. de Brugge, P.J. ter Hamburg, J.P. van Diepstraten, H.J.A. Loo, P.F. van Kersseboom, R. Hendriks, R.W. |
2010-02-18
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1,25-Dihydroxyvitamin D3 modulates Th17 polarization and interleukin-22 expression by memory T cells from patients with early rheumatoid arthritis
(Article)
Colin, E.M. Asmawidjaja, P. Hamburg, J.P. van Mus, A.M.C. Driel, M. van Hazes, J.M.W. Leeuwen, J.P.T.M. van Lubberts, E.W. |
2010-01-01
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Interleukin-23 is critical for full-blown expression of a non-autoimmune destructive arthritis and regulates interleukin-17A and RORγt in γδ T cells
(Article)
Cornelissen, F.H.J. Mus, A.M.C. Asmawidjaja, P. Hamburg, J.P. van Tocker, J. Lubberts, E.W. |
2009-12-17
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GATA-3 protects against severe joint inflammation and bone erosion and reduces differentiation of Th17 cells during experimental arthritis
(Article)
Hamburg, J.P. van Mus, A.M. Bruijn, M.J.W. de Vogel, L. de Boon, L. Cornelissen, F.H.J. Asmawidjaja, P. Hendriks, R.W. Lubberts, E.W. |
2009-03-01
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Role of GATA Transcription Factors in the T Cell Lineage
(Doctoral Thesis)
Hamburg, J.P. van |
2008-10-01
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Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology
(Article)
Hamburg, J.P. van Bruijn, M.J.W. de Ribeiro de Almeida, C. Zwam, M. van Meurs, M. van Haas, E.F. de Boon, L. Samsom, J.N. Hendriks, R.W. |
2008-09-01
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