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study association osteoarthritis knee oa control hip oa cohort rotterdam university allele rotterdam study research rheum effect polymorphism variant radiographic analysis result sample meta-analysi table arthritis cartilage phenotype finition genome-wide women chingford study population department netherland chingford replication valde subject hand oa osteophyte patient knee osteoarthritis kerkhof genetic spector haplotype grade signi k /l score expression heterogeneity score disease finite gdf 5 figure hospital medicine spector td genotype frequency factor variation consortium center summary esr 2 gene evidence oxford twinsuk power model meulenbelt doherty health analyses protein value osteoporotic fractures ficant genet meulenbelt i
10 Most Recent Publications
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A variant in MCF2L is associated with osteoarthritis
(Article)
Day-Williams, A.G. Southam, L. Keis, A. Kerkhof, H.J.M. Thorleifsson, G. Arden, N.K. Carr, A. Chapman, K. Deloukas, P. Loughlin, J. McCaskie, A. Ollier, W.E.R. Panoutsopoulou, K. Ralston, S.H. Spector, T.D. Wallis, G.A. Wilkinson, J.M. Aslam, N. Birell, F. Carluke, I. Joseph, J. Rai, A. Reed, M. Rayner, N.W. Walker, K. Doherty, S.A. Jonsdottir, I. Maciewicz, R.A. Muir, K.R. Metspalu, A. Rivadeneira Ramirez, F. Stefansson, K. Styrkarsdottir, U. Uitterlinden, A.G. Esko, T. Meurs, J.B.J. van Zhang, W. Valdes, A.M. Zeggini, E. Estrada Gil, J.K. Helgadottir, H.T. Hofman, A. Ingvarsson, T. Jonsson, H. |
2011-09-09
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The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genome-wide statistical significance
(Article)
Valdes, A.M. Evangelou, E. Cooper, C. Dennison, E.M. Zhang, W. Muir, K.R. Ioannidis, J.P.A. Wheeler, M. Maciewicz, R.A. Meurs, J.B.J. van Arden, N.K. Spector, T.D. Kerkhof, H.J.M. Tamm, A.E. Doherty, S.A. Kisand, K. Kerna, I. Uitterlinden, A.G. Hofman, A. Rivadeneira Ramirez, F. |
2011-05-01
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Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study
(Article)
Panoutsopoulou, K. Southam, L. Deloukas, P. Doherty, M. McCaskie, A. Ollier, W.E.R. Ralston, S.H. Spector, T.D. Valdes, A.M. Wallis, G.A. Wilkinson, J.M. Battley, K. Elliott, K.S. Blackburn, H. Blanco, F.J. Bumpstead, S. Cupples, L.A. Day-Williams, A.G. Dixon, K. Esko, T. Evangelou, E. Felson, D. Gómez-Reino, J.J. Wrayner, N. Gonzalez, A. Gordon, A. Gwilliam, R. Halldorsson, B.V. Hauksson, V.B. Hofman, B. Hunt, S.E. Ioannidis, J.P.A. Ingvarsson, T. Jonsdottir, I. Zhai, G. Jonsson, H. Keen, R. Kerkhof, H.J.M. Kloppenburg, M. Koller, N. Lakenberg, N. Lane, N.E. Lee, A.T. Metspalu, A. Meulenbelt, I. Beazley, C. Nevitt, M.C. O'Neill, F. Parimi, N. Potter, S.C. Rego-Perez, I. Riancho, J.A. Sherburn, K. Slagboom, P.E. Stefansson, K. Styrkarsdottir, U. Thorleifsson, G. Sumillera, M. Swift, D. Thorsteinsdottir, U. Tsezou, A. Uitterlinden, A.G. Meurs, J.B.J. van Watkins, B. Wheeler, M. Mitchell, S. Zhu, Y. Arden, N.K. Zmuda, J.M. Zeggini, E. Loughlin, J. Carr, A.M. Chapman, K. |
2011-05-01
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Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis
(Article)
Kerkhof, H.J.M. Doherty, M. Hart, D.J. Hofman, A. Javaid, K. Kerna, I. Kisand, K. Kloppenburg, M. Krasnokutsky, S. Maciewicz, R.A. Meulenbelt, I. Muir, K.R. Arden, N.K. Rivadeneira Ramirez, F. Samuels, J. Sezgin, M. Slagboom, E.P. Smith, A.J.P. Spector, T.D. Tamm, A. Uitterlinden, A.G. Wheeler, M. Zhai, G. Abramson, S.B. Zhang, W. Meurs, J.B.J. van Valdes, A.M. Attur, M. Bos, S.D. Cooper, C. Dennison, E.M. Doherty, S.A. Evangelou, E. |
2011-03-01
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Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: The TREAT-OA consortium
(Article)
Kerkhof, H.J.M. Meulenbelt, I. Doherty, S.A. Felson, D. Gonzalez, A. Gordon, A. Harilainen, A. Hart, D.J. Hauksson, V.B. Heliovaara, M. Hofman, A. Ikegawa, S. Akune, T. Ingvarsson, T. Jiang, Q. Jonsson, H. Jonsdottir, I. Kawaguchi, H. Kloppenburg, M. Kujala, U.M. Lane, N.E. Leino-Arjas, P. Lohmander, L.S. Arden, N.K. Luyten, F.P. Malizos, K.N. Nakajima, M. Nevitt, M.C. Pols, H.A.P. Rivadeneira Ramirez, F. Shi, D. Slagboom, E. Spector, T.D. Stefansson, K. Aromaa, A. Sudo, A. Tamm, A. Tamm, A.E. Tsezou, A. Uchida, A. Uitterlinden, A.G. Wilkinson, J.M. Yoshimura, N. Valdes, A.M. Meurs, J.B.J. van Bierma-Zeinstra, S.M.A. Carr, A.M. Cooper, C. Dai, J. Doherty, M. |
2011-03-01
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GDF5 single-nucleotide polymorphism rs143383 is associated with lumbar disc degeneration in Northern European women
(Article)
Williams, F.M.K. Popham, M. Valdes, A.M. Meurs, J.B.J. van Hart, D.J. Schepper, E.I.T. de Bierma-Zeinstra, S.M.A. Hofman, B. Uitterlinden, A.G. Arden, N.K. Cooper, C. Spector, T.D. |
2011-03-01
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Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22
(Article)
Evangelou, E. Valdes, A.M. Rayner, N.W. Southam, L. Zhai, G. Elliot, K.S. Hunt, S.E. Kerkhof, H.J.M. Styrkarsdottir, U. Zhu, Y. Meulenbelt, I. Lories, R.J. Karassa, F.B. Tylzanowski, P. Bos, S.D. |
2011-02-01
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Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: Results of a meta-analysis
(Article)
Kerkhof, H.J.M. Meulenbelt, I. Pols, H.A.P. Rivadeneira Ramirez, F. Slagboom, E. Spector, T.D. Stolk, L. Tsezou, A. Uitterlinden, A.G. Valdes, A.M. Meurs, J.B.J. van Carr, A.M. Gonzalez, A. Hart, D.J. Hofman, A. Kloppenburg, M. Lane, N.E. Loughlin, J. Nevitt, M.C. |
2010-11-16
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A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22
(Article)
Kerkhof, H.J.M. Lories, R.J. Thorleifsson, G. Zhai, G. Zhang, F. Zhu, Y. Breggen, R. van der Carr, A.M. Doherty, M. Felson, D. Gonzalez, A. Halldorsson, B.V. Meulenbelt, I. Hart, D.J. Hauksson, V.B. Hofman, A. Ioannidis, J.P.A. Kloppenburg, M. Lane, N.E. Loughlin, J. Luyten, F.P. Nevitt, M.C. Parimi, N. Jonsdottir, I. Pols, H.A.P. Rivadeneira Ramirez, F. Slagboom, E. Styrkarsdottir, U. Tsezou, A. Putte, T. van de Zmuda, J. Spector, T.D. Zwart, J-A. Uitterlinden, A.G. Valdes, A.M. Meurs, J.B.J. van Arp, P.P. Ingvarsson, T. Jhamai, M. Jonsson, H. Stolk, L. |
2010-02-01
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Variation at the ANP32A gene is associated with risk of hip osteoarthritis in women
(Article)
Valdes, A.M. Lories, R.J. Spector, T.D. Meurs, J.B.J. van Kerkhof, H.J.M. Doherty, S. Hofman, A. Hart, D.J. Zhang, F. Luyten, F.P. Uitterlinden, A.G. |
2009-07-01
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