Janssens, H.M.

spacer aerosol children delivery deposition study model particle breathing infant airway lung dose variability filter aerosol delivery asthma dose variability child device inhaled nebuchamber group plastic face mask pattern volume inhaler lung deposition inhalation babyhaler charge dose delivery therapy administration respir effect aerosol therapy plastic spacers result /spacer budesonide hfa-bdp figure breathing patterns group i breathing pattern metal cfc-bdp method adult cooperation filter dose detergent patient treatment within-subject technique aerosol deposition administration procedure factor drug delivery particle size plastic spacer pediatr devadason sg spacer devices metal spacer nebulizer difference airway model breathing simulator actuation inspiratory dose inhaler particle size distribution amount range saint model distribution comparison