Bruin-Versteeg, S. de

patient mutation rearrangement lymphocytes blood b-cell expression table lymphocyte artemi recombination precursor b-cell compartment protein xla patients infant analysis precursor subpopulation chain sample count differentiation bm samples adult children leukemia level receptor t lymphocytes light arrest b lymphocytes recombination activity lymphocyte subpopulations 0.0 cytometric activity immunol rotterdam 0.1 b cells precursor b cells number disease allele ifn -γ artemis gene mutations absence compartment nk cells rag genes study infection result defect frequency control immunoglobulin cd 38 b-cell differentiation arrest patient 2 rag 1 university rag-deficient scid patients fibroblast marker stage domain birth composition population kinase van dongen jjm unlysed erythrocytes figure deletion rs-scid artemis gene development cd 22