Verkaik, N.S.

protein recombination dna-pkc patient mutation artemi repair activity dna-pk dna ends analysis kinase figure reaction level autophosphorylation result assay product expression ligation rag 1 rev 3/ cells defect dna-dependent protein kinase m 3 cells substrate ligase rearrangement wild-type presence coding rev 3 end-joining sequence number formation damage control fibroblast irradiation pathway dna substrate rag 1 protein microhomology phase table dna-pkcs autophosphorylation recombination activity absence b-cell dna termini mirna coding joints sensitivity deletion terminus blood precursor chromosomal precursor b-cell compartment signal fragment uv irradiation carboxy nbs 1 checkpoint reaction mixtures termini digestion treatment dna damage region processing junction microhomology use transfected rs-scid break cycle