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renin prorenin aliskiren level plasma angiotensin concentration patient inhibitor study hypertension assay danser ahj receptor effect ang i – schalekamp madh figure heart danser activity medium angiotensinogen activation enzyme polymorphism ang i subject conversion result swets subs service renin levels quinaprilat prorenin levels bradykinin saxena pr 37° c diabetes derkx fhm genotype control presence mast cells release nephropathy cisbio urine c-domain blood ang ii sample plasma renin ang ii generation schalekamp albumin antibody inhibition incubation aldosterone protein tissue binding table treatment innovations elisa n-domain group cisbio irma elisa angiotensin-converting enzyme minute serum culture medium renin release increase generation absence stimulation domain detection
10 Most Recent Publications
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New renin inhibitor VTP-27999 alters renin immunoreactivity and does not unfold prorenin
(Article)
Krop, M. Lu, X. Verdonk, K. Schalekamp, M.A.D.H. Gool, J.M. van McKeever, B.M. Gregg, R.G. Danser, A.H.J. |
2013-05-01
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Urinary renin, but not angiotensinogen or aldosterone, reflects the renal renin-angiotensin-aldosterone system activity and the efficacy of renin-angiotensin-aldosterone system blockade in the kidney
(Article)
Heuvel, M. van den Batenburg, W.W. Jainandunsing, S. Garrelds, I.M. Gool, J.M. van Feelders, R.A. Meiracker, A.H. van den Danser, A.H.J. |
2011-11-01
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Evaluation of a direct prorenin assay making use of a monoclonal antibody directed against residues 32-39 of the prosegment
(Article)
Krop, M. Gool, J.M. van Day, D. Hollenberg, N.K. Danser, A.H.J. |
2011-11-01
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Cardiac renin levels are not influenced by the amount of resident mast cells
(Article)
Krop, M. Veghel, R. van Garrelds, I.M. Bruin, R.J.A. de Gool, J.M. van Meiracker, A.H. van den Thio, M. Daele, P.L.A. van Danser, A.H.J. |
2009-08-01
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Aliskiren accumulates in renin secretory granules and binds plasma prorenin
(Article)
Krop, M. Garrelds, I.M. Bruin, R.J.A. de Gool, J.M. van Fisher, N.D.L. Hollenberg, N.K. Danser, A.H.J. |
2008-12-01
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Aliskiren-binding increases the half life of renin and prorenin in rat aortic vascular smooth muscle cells
(Article)
Batenburg, W.W. Bruin, R.J.A. de Gool, J.M. van Müller, D. Bader, M. Nguyen, G. Danser, A.H.J. |
2008-06-01
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Different contributions of the angiotensin-converting enzyme C-domain and N-domain in subjects with the angiotensin-converting enzyme II and DD genotype
(Article)
Esch, J.H.M. van Gool, J.M. van Bruin, R.J.A. de Payne, J.R. Montgomery, H.E. Hectors, M. Deinum, J. Dive, V. Danser, A.H.J. |
2008-04-01
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Selective angiotensin-converting enzyme C-domain inhibition is sufficient to prevent angiotensin I-induced vasoconstriction.
(Article)
Esch, J.H.M. van Tom, B. Dive, V. Batenburg, W.W. Georgiadis, D. Yiotakis, A. Gool, J.M. van Bruijn, R.J. de Vries, R. de Danser, A.H.J. |
2005-01-01
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Angiotensin II type 2 receptors and cardiac hypertrophy in women with hypertrophic cardiomyopathy
(Article)
Deinum, J. Gool, J.M. van Kofflard, M.J.M. Danser, A.H.J. Cate, F.J. ten |
2001-01-01
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Plasma renin and prorenin and renin gene variation in patients with insulin-dependent diabetes mellitus and nephropathy
(Article)
Deinum, J. Tarnow, L. Gool, J.M. van Bruin, R.J.A. de Derkx, F.H.M. Schalekamp, M.A.D.H. Parving, H.H. |
1999-01-01
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