Denderen, A.C. van

protein leukemia patient bcr-abl chromosome chimeric antibody junction peptide tumor breakpoint translocation tumor-specific sequence antiserum figure philadelphia 190bcr kinase fusion myeloid leukemia result mutation lymphoblastic leukemia grosveld g region chapter point mutations binding myeloid study analysis cancer p 190bcr philadelphia chromosome blood point groffen j lymphoblastic eiwitten tyrosine kinase activity er-fp grosveld er-fp 1 leukemic cells tyrosine domain fragment ph chromosome chain polymerase chain reaction diagnosis heisterkamp n factor chromosomal activity nature immunoprecipitation function 210bcr molecule control transcription ber gene oncogene sp b 3-a ber-abl abl gene detection bcr-abl chimeric proteins reaction heisterkamp expression fusion-point m-bcr blast ph-positive product cell lines characterization