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substrate protein ercc 1-xpf 1-xpf repair 21+/2 single-stranded binding activity strand crypt ercc 1 nucleotide nuclease incisions interaction ssdna ercc 1xpf rad 21+/2 mice replication duplex region junction assay replication protein incision domain cleavage position polarity formation 1–xpf nucleotide excision repair excision ercc 1–xpf buffer rad 21+/2 mefs rad 21 patient rad 21+/2 cells ttd 1ro coli ssb protein single-stranded arms recombination duplex dna animal antibody presence mutation endonuclease 28- radiation rad 21+/2 reaction response structure figure analysis product stem-loop group downloaded affinity transcription number residue result survival level sequence dna substrates dna junction rad 21+/2 animals lesion mouse process ercc 1 protein ch 2ax foci erasmus mc structure-specific
9 Most Recent Publications
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Rad21-cohesin haploinsufficiency impedes DNA repair and enhances gastrointestinal radiosensitivity in mice
(Article)
Xu, H. Balakrishnan, K. Lavin, M.F. Bertonchello, I. Ramsay, R.G. Mckay, M.J. Malaterre, J. Beasley, M. Yan, Y. Essers, J. Appeldoorn, E. Thomaszewski, J.M. Vazquez, M. Verschoor, S. |
2010-10-19
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A temperature-sensitive disorder in basal transcription and DNA repair in man
(Letter To Editor)
Vermeulen, W. Rademakers, S. Jaspers, N.G.J. Appeldoorn, E. Raams, A. Klein, B. Kjærsgård, L. Hoeijmakers, J.H.J. Kleijer, W.J. |
2001-03-20
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Mapping of the interaction domains between human repair proteins ERCC1 and XPF.
(Article)
Laat, W.L. de Sijbers, A.M. Odijk, H. Appeldoorn, E. Jaspers, N.G.J. Hoeijmakers, J.H.J. |
1998-09-15
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DNA structural elements required for ERCC1-XPF endonuclease activity.
(Article)
Laat, W.L. de Appeldoorn, E. Jaspers, N.G.J. Hoeijmakers, J.H.J. |
1998-04-03
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DNA-binding polarity of human replication protein A positions nucleases in nucleotide excision repair.
(Article)
Laat, W.L. de Appeldoorn, E. Sugasawa, K. Jaspers, N.G.J. Hoeijmakers, J.H.J. |
1998-01-01
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DNA structural elements required for ERCC1-XPF endonuclease activity
(Article)
Laat, W.L. de Appeldoorn, E. Hoeijmakers, J.H.J. Jaspers, N.G.J. |
1998-01-01
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DNA-binding polarity of human replication protein A positions nucleases in nucleotide excision repair
(Article)
Laat, W.L. de Appeldoorn, E. Sugasawa, K. Weterings, E. Hoeijmakers, J.H.J. Jaspers, N.G.J. |
1998-01-01
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Correction of xeroderma pigmentosum repair defect by basal transcription factor BTF2/TFIIH.
(Article)
Vuuren, A.J. van Vermeulen, W. Egly, J-M. Ma, L. Weeda, G. Appeldoorn, E. Jaspers, N.G.J. Eb, A.J. van der Hoeijmakers, J.H.J. Humbert, S. Schaeffer, L. |
1994-01-01
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Evidence for a repair enzyme complex involving ERCC1, and the correcting activities of ERCC4, ERCC11 and the xeroderma pigmentosum group F.
(Article)
Vuuren, A.J. van Appeldoorn, E. Odijk, H. Yasui, A. Jaspers, N.G.J. Bootsma, D. Hoeijmakers, J.H.J. |
1993-01-01
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