Coloma, P.M.

event database safety method drug safety study signal system health drug reactions incidence drug safety monitoring pharmacovigilance eu-adr reaction monitoring detection 2010 john wiley eu-adr project patient protopathic bias hospital exposure record 2009 john wiley 10.1002/ incidence rates project pharmacoepidemiol drug events leopard wiley surveillance emergency department visit gamma poisson shrinker mining prescription pharmacoepidemiol drug saf nsaid european performance association italy effect department pharmacoepidemiology table estimate score copyright information ratio result drug-induced ehr databases number signal detection admission country withdrawal healthcare data mining protopathic control figure population failure hospital admissions drug safety signals fication netherland disease infarction drug withdrawals population-based review network reference emergency research