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patient fatigue biliary cirrhosis study disease cirrhosis biliary depression score liver concentration sclerosing cholangitis treatment group cholangiti serum disorder control glucocorticoid tips placement result survival tyrosine table effect sclerosing difference follow-up oxidative stress quality fluvoxamine level prevalence gastroenterology domain shunt activity bilirubin receptor chapter severity cholestatic liver disease diagnosis placement number model ursodeoxycholic acid factor symptom scale presence cholestatic liver diseases analysis correlation hepatology trial plasma expression tyrosine concentrations serum bilirubin criteria stress variant oxidative hgr mrna encephalopathy population range glucocorticoid resistance albumin pbc patients cholestatic acid concentrations disease activity relation impact department phosphatase intrahepatic prognostic factors