Schroyens, W.

patient fviii fatigue willebrand ddavp treatment von willebrand disease disease vwd type 1 study group level factor mutation response blood vwf multimers vwf parameters table /medium fatigue vs multimer score type 1 type 2 von willebrand factor >250 erasmus univ rotterdam value fviii /vwf ratio jak 2v mutation fatigue vs michiel surgery hrqol parameter month vwf /fviii assessment loading dose recessive haemate-p marrow /medium diagnosis scale type 2 vwd jak 2v thromb symptom haematol loading missense vwd patients criteria presence platelet domain thrombocythemia bone marrow features infusion blood group /fviii quality hodgkin alphanate -20 allele absence activity feature trial hemate-p rotterdam vwf deficiency prophylaxi european half life times erasmu plasma