Gourdin, A.M.

repair protein damage pol ␩ lesion draq 5 synthesis excision factor incision polymerase binding repair synthesis accumulation nucleotide excision repair model replication nucleotide dna repair result figure uv damage ubiquitination chromatin dna damage mobility pol ␫ rnf 8 dna lesions transcription dna repair synthesis ercc 1-xpf assembly complex vermeulen irradiation uv-induced tfiih kinetic ubc 13 53 bp 1 mdc 1 uv irradiation activity intermediate number analysis recruitment effect mechanism study nucleus reaction houtsmuller ner factors level ner proteins gfp-ub uorescence wild-type response process 6-4 histone fl uorescence repair intermediates downloaded jcb.rupress.org ficient recognition dissociation replication foci treatment 30 incision concentration interaction 1-xpf affinity experiment specificity