Staresincic, L.

repair protein fen -1-xpg incision activity substrate synthesis figure -1-xpg repair synthesis excision region spacer region ercc 1-xpf nucleotide damage dna repair synthesis nucleotide excision repair spacer nuclease uv damage study cleavage wild-type recruitment reaction ner activity product binding 1-xpf 30 incision puri fied lesion presence bubble ner l staresincic speci xpg spacer region endonuclease fen -1-xpg protein 6-4 pps ficient factor oligonucleotide assay wild-type xpg uv irradiation acids research tfiih xpf-d 676a 6-4 result irradiation 2009 european repair synthesis steps xp-g /cs cells 50 incision structure untransduced interaction replication catalytically transduced transductant level wild-type xpf mechanism cell extracts xpg protein bubble substrates post-uv polymerase incisions fl ap substrate repair synthesis products extract domain fl exible loop figure 7 b substrate speci ficity