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hbsag antibody anti-hb vaccine binding hepatitis 9 h 9 peptide phase assay hbs.ot serum sample 4-7 b heijtink inhibition tuvirumab 4-7 epitope conjugate 1 ff 4 anti- hepatitis b vaccine antigen study virus level result experiment complex mouse signal chimpanzee amount response subtype surface vaccination reference f 4-7b plasma-derived particle patient plasma hbs.ot 40 anti-pre variant change hansenula-derived serum anti-hbs chimpanzee hbsag hb-vax hbsag /adw adw 2 speci yeast preparation anti-hbs antibodies reduction activity hbsag /tuvirumab complexes titrated amounts binding assay month f 4-7b conjugate infection dilution hbs.ot 42 therapy hepatitis b virus hepatect engerix-b treatment vaccinee hb-vax-dna hbsag particles fluence table detection rhbsag