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locus chromosome transcription interaction region b-globin b-globin locus globin expression chromatin study sample liver element probe contact gene expression signal 8 c 3–c genome 4 c technology sequence analysis chromosomal organization translocation figure genomic gene loci β- globin locus enhancer chromosome 7 rearrangement rnapii fragment liver cells erythroid technology dna elements level promoter a-amanitin nucleus 4 c data nature position mouse rna polymerase ii genet breakpoint beta-globin factor experiment dna interactions viewpoint rad 23a locus β- globin genes frequency hlcr-a interchromosomal control protein e 14.5 β h 1 transcription factors right cryo-fish method b-globin genes activation ectopic lcr transcription inhibition number grosveld 3 c technology image 4 c signals erythroid cells looping cluster
5 Most Recent Publications
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Variegated gene expression caused by cell-specific long-range DNA interactions
(Article)
Noordermeer, D. Wit, E. de Klous, P. Werken, H.J.G. van de Simonis, M. Lopez-Jones, M. Eussen, B.H.J. Klein, J.E.M.M. de Singer, R.H. Laat, W.L. de |
2011-08-01
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High-resolution identification of balanced and complex chromosomal rearrangements by 4C technology
(Article)
Simonis, M. Klous, P. Homminga, I. Galjaard, R-J.H. Rijkers, E.J. Grosveld, F.G. Meijerink, J.P.P. Laat, W.L. de |
2009-10-15
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FISH-eyed and genome-wide views on the spatial organisation of gene expression
(Article)
Simonis, M. Laat, W.L. de |
2008-11-01
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Maintenane of long-range DNA interactions after inhibition of ongoing RNA polymerase II transcription
(Article)
Palstra, R.J.T.S. Simonis, M. Klous, P. Brasset, E. Eijkelkamp, B. Laat, W.L. de |
2008-02-20
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Three-Dimensional Organization of Gene Expression in Erythroid Cells
(Article)
Laat, W.L. de Klous, P. Kooren, J.A. Noordermeer, D. Palstra, R.J.T.S. Simonis, M. Splinter, D. Grosveld, F.G. |
2008-02-18
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