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t-all leukemia patient expression notch sample lymphoblastic leukemia figure mef 2c mutation t-cell forodesine analysis lymphoblastic translocation cancer deletion cluster level rearrangement tlx 3 notch 1 t-all cases 2-1 chromosome study chromosomal nkx 2-1 region ara-g oncogene dexamethasone blood table treatment control t-all patients breakpoint chapter effect genomic protein result fbxw 7 mutations target identi fied aberration subgroups tumor proliferative signal development homeobox activation bcp-all factor lmo 2 method glucocorticoid patient samples lyl 1 identi nkl genes fusion oncogenic concentration cutll 1 cells notch 1 mutations /dguo fish analysis outcome 2-5 sensitivity cohort analyses array-cgh t-all samples protocol transcription abnormality
6 Most Recent Publications
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Gene-expression profiles and oncogenes in pediatric T-cell acute lymphoblastic leukemia
(Doctoral Thesis)
Homminga, I. |
2011-11-30
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In vitro efficacy of forodesine and nelarabine (ara-G) in pediatric leukemia
(Article)
Homminga, I. Zwaan, C.M. Manz, C.Y. Parker, C. Bantia, S. Smits, W.K. Higginbotham, F. Pieters, R. Meijerink, J.P.P. |
2011-08-25
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Integrated Transcript and Genome Analyses Reveal NKX2-1 and MEF2C as Potential Oncogenes in T Cell Acute Lymphoblastic Leukemia
(Article)
Homminga, I. Pieters, R. Vlierberghe, P. van Ferrando, A.A. Cayuela, J.M. Verhaaf, B. Beverloo, H.B. Horstmann, M. Haas, V. de Wiekmeijer, A.-S. Pike-Overzet, K. Staal, F.J.T. Langerak, A.W. Laat, W.L. de Soulier, J. Sigaux, F. Meijerink, J.P.P. Rooi, J.J. de Stubbs, A. Verstegen, M.M.A. Vuerhard, M.J. Buijs-Gladdines, J.G.C.A.M. Kooi, C. Klous, P. |
2011-04-12
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High-resolution identification of balanced and complex chromosomal rearrangements by 4C technology
(Article)
Simonis, M. Klous, P. Homminga, I. Galjaard, R-J.H. Rijkers, E.J. Grosveld, F.G. Meijerink, J.P.P. Laat, W.L. de |
2009-10-15
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γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia
(Article)
Real, P.J. Tosello, V. Meijerink, J.P.P. Aifantis, I. Basso, G. Cordon-Cardo, C. Ai, W. Ferrando, A.A. Palomero, T. Castillo, M. Hernando, E. Stanchina, E. de Sulis, M.L. Barnes, K. Sawai, C. Homminga, I. |
2009-01-01
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Cooperative genetic defects in TLX3 rearranged pediatric T-ALL
(Article)
Vlierberghe, P. van Homminga, I. Zuurbier, L. Buijs-Gladdines, J.G.C.A.M. Wering, E.R. van Horstmann, M.A. Beverloo, H.B. Pieters, R. Meijerink, J.P.P. |
2008-04-01
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