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chromosome locus transcription expression interaction region globin b-globin chromatin figure 8 c 3/c b-globin locus analysis liver level x chromosome sample mef 2c t-all probe cluster factor promoter contact study rearrangement chromosomal organization gene expression sequence genome erythroid 4 c technology element control translocation fragment signal 8 c 3–c genomic position experiment mouse - globin locus 2-1 frequency e 14.5 liver cells i /11 cells identi fied b-globin lcr nature histone chromosome 7 rnapii 14.5 table result viewpoint breakpoint genet a-amanitin binding nkx 2-1 4 c data enhancer method differentiation protein number patient rna polymerase ii technology transcription factors identi formation β- globin locus cancer leukemia dna elements
8 Most Recent Publications
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Variegated gene expression caused by cell-specific long-range DNA interactions
(Article)
Noordermeer, D. Wit, E. de Klous, P. Werken, H.J.G. van de Simonis, M. Lopez-Jones, M. Eussen, B.H.J. Klein, J.E.M.M. de Singer, R.H. Laat, W.L. de |
2011-08-01
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The inactive X chromosome adopts a unique three-dimensional conformation that is dependent on Xist RNA
(Article)
Splinter, D. Wit, E. de Laat, W.L. de Nora, E.P. Klous, P. Werken, H.J.G. van de Zhu, Y. Kaaij, L.J.T. IJcken, W.F.J. van Gribnau, J.H. Heard, E. |
2011-07-01
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Integrated Transcript and Genome Analyses Reveal NKX2-1 and MEF2C as Potential Oncogenes in T Cell Acute Lymphoblastic Leukemia
(Article)
Homminga, I. Pieters, R. Vlierberghe, P. van Ferrando, A.A. Cayuela, J.M. Verhaaf, B. Beverloo, H.B. Horstmann, M. Haas, V. de Wiekmeijer, A.-S. Pike-Overzet, K. Staal, F.J.T. Langerak, A.W. Laat, W.L. de Soulier, J. Sigaux, F. Meijerink, J.P.P. Rooi, J.J. de Stubbs, A. Verstegen, M.M.A. Vuerhard, M.J. Buijs-Gladdines, J.G.C.A.M. Kooi, C. Klous, P. |
2011-04-12
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High-resolution identification of balanced and complex chromosomal rearrangements by 4C technology
(Article)
Simonis, M. Klous, P. Homminga, I. Galjaard, R-J.H. Rijkers, E.J. Grosveld, F.G. Meijerink, J.P.P. Laat, W.L. de |
2009-10-15
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Transcription and chromatin organization of a housekeeping gene cluster containing an integrated β-globin locus control region
(Article)
Noordermeer, D. Branco, M.R. Splinter, D. Klous, P. IJcken, W.F.J. van Swagemakers, S.M.A. Koutsourakis, M. Spek, P.J. van der Pombo, A. Laat, W.L. de |
2008-03-01
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Maintenane of long-range DNA interactions after inhibition of ongoing RNA polymerase II transcription
(Article)
Palstra, R.J.T.S. Simonis, M. Klous, P. Brasset, E. Eijkelkamp, B. Laat, W.L. de |
2008-02-20
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Three-Dimensional Organization of Gene Expression in Erythroid Cells
(Article)
Laat, W.L. de Klous, P. Kooren, J.A. Noordermeer, D. Palstra, R.J.T.S. Simonis, M. Splinter, D. Grosveld, F.G. |
2008-02-18
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β-Globin active chromatin hub formation in differentiating erythroid cells and in p45 NF-E2 knock-out mice
(Article)
Kooren, J.A. Palstra, R.J.T.S. Klous, P. Splinter, D. Lindern, M.M. von Grosveld, F.G. Laat, W.L. de |
2007-06-01
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