http://repub.eur.nl/res/aut/31826/ List of Publications en http://repub.eur.nl/static-eur/img/logo.png http://repub.eur.nl http://repub.eur.nl/res/pub/26375/ 2011-05-19T00:00:00Z Purpose: This study reevaluates the potential role of different tumour markers as prognostic indicators in untreated nephroblastoma. Methods: Expression of a broad panel of tumour markers was investigated by means of immunohistochemical analysis in 43 WT patients. Patients were treated by radical nephrectomy and had a mean follow-up of 11.9 years. Results: Generally, all the tumour markers studied were expressed in normal kidney tissue and at variable levels in the three cell types of WT (blastema, epithelium and stroma). Immunoreactive blastemal (Bcl-X, Bcl-2 and CD44s) and epithelial (Bcl-X, Bcl-2 and MIB-1) cells were present in the majority of tumours. No correlation was found between their expression and pathological stages. Univariate analysis showed that blastemal WT-1, TGF-α, VEGF, MIB-1 and p27 Kip1 were indicative for clinical progression. In a multivariate analysis, WT-1 protein expression by blastemal cells was an independent prognostic marker for clinical progression. Conclusions: The blastemal WT-1, TGF-α, VEGF, MIB-1 and p27Kip1 expression correlate with clinical progression in untreated nephroblastoma. Therefore, their expression may be of value in identifying patients with a high propensity to develop distant metastases. http://repub.eur.nl/res/pub/24609/ 2009-12-04T00:00:00Z Background: The quality of teachers in higher education is subject of increasing attention, as exemplified by the development and implementation of guidelines for teacher qualifications at Universities in The Netherlands. Aim: Because medical education takes a special position in higher education the Council of Deans of Medical Schools in The Netherlands installed a national task force to explore a method to weigh criteria for teacher qualifications of medical teachers. Methods: A framework was developed covering competencies of teachers throughout the medical education continuum and including medicine, dentistry and veterinary medicine. Results: The framework distinguishes 3 dimensions: (a) six domains of teaching (development organization execution coaching assessment evaluation); (b) three levels in the organization at which teachers perform (micro, meso and macro level) and (c) competencies as integration of knowledge, skills and attitude and described as behaviour in specific context. The current framework is the result of several cycles of descriptions, feedback from the field and adaptations. It is meant as a guideline, leaving room for local detailing. Conclusion: The framework provides a common language that may be used not only by teachers and teacher trainers, but also by quality assurance committees, human resource managers and institutional boards. http://repub.eur.nl/res/pub/26170/ 1977-10-05T00:00:00Z In the spinal cord the neuronal cell bodies are located in the spinal gray matter, which may be subdivided into a dorsal horn, a ventral horn and an intermediate zone. Neurons in the dorsal horn give rise mainly to long ascending fibers, while the motoneurons of the ventral horn innervate the musculature of body and limbs. The intermediate zone harbours the majority of propriospinal neurons, which differ from other spinal neurons in that not only their cell bodies, but also their terminal axonal projections are located within the spinal gray matter.