Oellerich, M.

patient transplantation study transplant mycophenolic acid mycophenolate mofetil concentration mycophenolate mycophenolic mofetil group recipient transplant recipients exposure pharmacokinetic month value method cyclosporine plasma mmf dose drug monitoring diarrhea mpa exposure acmpag metabolite mpa-auc event mpa auc 0–12 table assay analysis glucuronide tacrolimu incidence difference treatment result figure level monitoring regimen 0–12 armstrong vw roche time points rejection 1000 mg mmf visit point center lc –ms mpa cl /f mpa concentrations diarrhoea department monit fixed-dose sample signi ficantly comparison number conditioning signi episode kidney trial donor therapy range +++ hoffmann-la roche ltd drug monit curve university mpa assay target mmf doses treatment failure relationship