View Author
scopus: 12645649100

Kappers, M.H.W.

(Mariette Kappers)


sunitinib patient hypertension treatment effect receptor study inhibition pressure thyroid inhibitor angiogenesi blood factor angiogenesis inhibition level proteinuria blood pressure sunitinib-induced toxicity increase kinase endothelin administration cell carcinoma change nitric macitentan cancer control oxide dysfunction decrease growth tyrosine mechanism nitric oxide therapy sunitinib treatment function chapter side effects development activation tumor metastatic oxidative stress sunitinib administration hypothyroidism growth factor figure bevacizumab vegfr protein baseline heart carcinoma vehicle van den meiracker response excretion kidney activity disease serum sunitinib withdrawal 8 days system sunitinib-induced hypertension stress endothelin system oncol capillary expression tempol table oxidative thyroid dysfunction tsh levels production




7 Most Recent Publications

Polymorphisms in endothelial nitric oxide synthase (eNOS) and vascular endothelial growth factor (VEGF) predict sunitinib-induced hypertension (Article)
Eechoute, K. Veldt, A.A.M. van der Mathijssen, R.H.J. Boven, E. Oosting, R.S. Kappers, M.H.W. Wessels, J.A.M. Gelderblom, H. Guchelaar, H.J. Reyners, A.K.L. Herpen, C.M.L. Haanen, J.B.
2012-10-01
Cardiovascular, renal and thyroid toxicity during angiogenesis inhibition: A translational approach (Doctoral Thesis)
Kappers, M.H.W.
2011-11-30
Re: Hypertension as a biomarker of efficacy in patients with metastatic renal cell carcinoma treated with sunitinib (Article)
Meiracker, A.H. van den Danser, A.H.J. Sleijfer, S. Kappers, M.H.W.
2011-10-19
Sunitinib-induced hypothyroidism is due to induction of type 3 deiodinase activity and thyroidal capillary regression (Article)
Kappers, M.H.W. Esch, J.H.M. van Visser, T.J. Smedts, F. Krijger, R.R. de Eechoute, K. Mathijssen, R.H.J. Sleijfer, S. Leijten, F.P.J. Danser, A.H.J. Meiracker, A.H. van den
2011-10-01
The vascular endothelial growth factor receptor inhibitor sunitinib causes a preeclampsia-like syndrome with activation of the endothelin system (Article)
Kappers, M.H.W. Smedts, F. Horn, T. Esch, J.H.M. van Sleijfer, S. Leijten, F.P.J. Wesseling, S. Strevens, H. Danser, A.H.J. Meiracker, A.H. van den
2011-08-01
Cardiovascular and renal toxicity during angiogenesis inhibition: Clinical and mechanistic aspects (Article)
Kappers, M.H.W. Esch, J.H.M. van Sleijfer, S. Danser, A.H.J. Meiracker, A.H. van den
2009-12-01
Light-induced vs. bradykinin-induced relaxation of coronary arteries: Do S-nitrosothiols act as endothelium-derived hyperpolarizing factors? (Article)
Batenburg, W.W. Kappers, M.H.W. Eikmann, M.J. Ramzan, S.N.A. Vries, R. de Danser, A.H.J.
2009-08-01