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c 1-inh patient study attack 1-inh treatment 1-inhibitor level inhibitor c 1-inhibitor angioedema injury etanercept protein activity effect pneumonia number protein c prophylactic lung injury tissue coagulation blood control pneumoniae netherland range group plasminogen antithrombin c 1 inhibitor activator saline factor anticoagulant c 4 levels product high-vt mice low-vt mice pathway heparin pharmacokinetic sepsis prophylactic study flammatory assay model cetor ventilation prophylactic treatment neutrophil response parameter low-vt 48 hrs lavage pneumoniae pneumonia placebo shock animal c 4 level amsterdam receptor medication alveolar safety score bronchoalveolar tissue plasminogen activator angioedema attacks lung homogenates flammatory response prophylaxi attenuate hae patients on-demand study distress syndrome efficacy process
3 Most Recent Publications
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Treatment of hereditary angioedema with nanofiltered C1-esterase inhibitor concentrate (Cetor®): Multi-center phase II and III studies to assess pharmacokinetics, clinical efficacy and safety
(Article)
Hofstra, J.J.H. Budde, I.K. Strengers, P.F.W. Twuyver, E. van Choi, G. Levi, M. Leebeek, F.W.G. Monchy, J.G. de Ypma, P.F. Keizer, R.J.W. de Huitema, A.D.R. |
2012-03-01
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Recombinant human soluble tumor necrosis factor-alpha receptor fusion protein partly attenuates ventilator-induced lung injury
(Article)
Wolthuis, E.K. Vlaar, A.P.J. Choi, G. Roelofs, J.J.T.H. Haitsma, J.J. Poll, T.D. van Juffermans, N.P. Zweers, M.M. Schultz, M.J. |
2009-03-01
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Antithrombin inhibits bronchoalveolar activation of coagulation and limits lung injury during Streptococcus pneumoniae pneumonia in rats
(Article)
Choi, G. Hofstra, J.J.H. Roelofs, J.J.T.H. Rijneveld, A.W. Bresser, P. Zee, J.S. van der Florquin, S. Poll, T. van der Levi, M. Schultz, M.J. |
2008-01-01
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