Gelder, T. van

patient study transplantation transplant concentration rejection mycophenolate mofetil recipient pharmacokinetic mycophenolate group mycophenolic acid transplant recipients exposure mofetil mycophenolic effect level kidney plasma mpa exposure result tacrolimu model treatment impdh table sample therapy month analysis variability number cyclosporine value genotype polymorphism clearance drug monitoring monitoring function activity tamoxifen blood difference heart method liver trial population antibody allele outcome cyp 2d genotype cancer transplant patients ec-mp graft cyp 3a cyp 2d impdh activity disease serum signi incidence kidney transplantation mpa auc 0–12 gelder pharmacol van gelder t order relationship bt 563 target hospital drug safety creatinine inhibitor sampling metabolite