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wound healing otr 4120 treatment tissue wound healing ulcer treatment collagen factor control growth rgta otr 4120 matrix 4120-treated heparan effect otr 4120-treated wounds sulfate otr 4120 strength otr 4120-treated ulcers growth factors signi study pressure repair caruelle jp regeneration control wounds group model figure flammation extracellular matrix protein pressure ulcers tissue regeneration barritault signi ficant differences injury heparan sulfate analysis hs-gag therapy growth factor cutaneou patient signi ficantly heparan sulfates signi ficant difference epidermal ficant content extracellular proliferation dermatol mechanism society animal expression skin perfusion administration difference matrix therapy heat provocation compression 4 1 c staining collagen type i caruelle reepithelialization granulation tissue compression release diabetes full-thicknes application granulation perfusion tgf-b cutaneous wound healing