Capellari, S.

disease prion patient mutation protein amyloid position prion protein cortex brain prion disease prpsc neuro fibrillary tangles plaque neuropathol deposit creutzfeldt-jakob disease creutzfeldt-jakob antibody prion protein gene analysis genotype prion diseases amyloid angiopathy cerebellum codon allele netherland polymorphism fragment accumulation dementia phenotype neuro duration residue fibrillary association cathepsin alzheimer y 226x mutation q 227x mutation month ??? patient 2 tangle angiopathy disease duration frontotemporal dementia result survival neurol study change deposition neurology number fi ndings centre prp-caa copyright © 2011 g 131v mutation blood vessels nding american association parchi gss disease sample distribution pathology signi tau accumulations novel amyloid depositions examination illness american codon mutations university neuropathologist