Molier, M.

androgen mutation receptor activity domain interaction binding f 826l ar f 826l androgen receptor wild-type expression assay activation protein wild-type ar presence ligand nc-tdi analysis residue transcriptional /well renilla luc activity wildtype ar patient transcriptional activity tif 2 co-activation cooh-terminal result n-cor cho cells tif 2 fxxlf insensitivity wildtype androgen insensitivity syndrome motif transfected trapman function study endocrinol skin fi broblasts medium concentration transcription hypospadia co-activation transactivation 3 ng /well penoscrotal hypospadias androgen insensitivity co-activator binding groove hep 3b cells 3 experiments ar-c-f 826l reporter ar gene hormone terminal testosterone co-activator wt ar-c jenster dna binding experiment coactivator groove r 1881 terminal domain ligand binding domain f 826l mutation ligand binding pocket region groove renilla brinkmann ar nh 2 mmtv-luc vector