Ellis, J.

transgene globin expression 5 hs 3 level liver bgt 14 number acids research fragment promoter element analysis 1 nuclease analysis gene therapy mouse therapy copy numbers copy transgenes 265 bp promoter concatamer blot analysis head dna grosveld globin gene probe animal research vector liver rna 5 hs 2 junction founder figure multicopy activity copy number cassette lcr activity copy transgene expression ivs 2 probe 5 hs 4 815 bp promoter panel ecori 3.0 hs core elements 3.0 kb lcr globin promoter footprint probe fragment virus control bamhi titer virus fl transgenes globin mrna copy animals dimer bgt 15 copy line globin expression transgene intactness hypersensitive sites nuclease sequence hypersensitive monomer fetus order dynamics phosphorimager 10.5 kb microlocus gene therapy applications mosaic f 0 fetuses dimer junctions 815 bp fl transgene concatamers novel lcr cassette copy transgene activation