Donker, I.

repair mouse activity wild-type agent protein glycosylase mutation cancer 1*292 analysis transcription ercc 1*292 mice tissue level defect group liver patient allele dna glycosylase activity ercc 1-mutant mice fragment ercc 1 knockout result figure embryo syndrome alkylating chemotherapeutic alkylating agents 1-mutant function xeroderma mtase fibroblast probe klc 2 gene –/– mgmt –/– mice lesion complementation sequence sensitivity excision /ercc effect extract dna repair control kidney trichothiodystrophy ercc 1 knockout alkylating agents chemotherapeutic pigmentosum survival treatment tfiih hoeijmaker clone animal xeroderma pigmentosum dna glycosylase aag mice vermeulen erasmus university rotterdam genomic methyltransferase weeda dna glycosylases ercc 1-mutant mefs cycle bamhi stage blot analysis cockayne syndrome genet method 6-meg