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muc 2à/à mice muc 2ϫ/ϫ mice expression colon muc 2þ/þ mice muc 2/il mice muc 2 promoter level wt mice muc 2 butyrate epithelial coliti goblet cells mucin signi goblet factor signi ficantly promoter crypt protein foxa 1 analysis muc 2 expression transcription foxa 2 response muc 2þ/þ ficantly cytokine ls 174t cells intestine figure flammatory increase cancer effect development study proliferation muc 2à/à histone concentration il -10à/à mice netherland 5 weeks change physiol number mucus layer tff 3 difference ficant pathway result -10 growth binding p 28. disease mucosal upregulated van der sluis length gene expression levels damage control 28. differentiation mtx-treatment mucositi epithelial cells morphology layer activity -10à/à speci function receptor
6 Most Recent Publications
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Colitis development during the suckling-weaning transition in mucin muc2-deficient mice
(Article)
Paassen, N.B.-V. Sluis, M. van der Bouma, J. Korteland-Van Male, A.M. Lu, P. Seuningen, I. van Boehm, G. Goudoever, J.B. van Renes, I.B. |
2011-10-01
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Colonic gene expression patterns of mucin muc2 knockout mice reveal various phases in colitis development
(Article)
Lu, P. Burger-van Paassen, N. Sluis, M. van der Witte-Bouma, J. Kerckaert, J.-P. Goudoever, J.B. van Seuningen, I. van Renes, I.B. |
2011-10-01
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The regulation of intestinal mucin MUC2 expression by short-chain fatty acids: Implications for epithelial protection
(Article)
Burger-van Paassen, N. Vincent, A. Puiman, P.J. Sluis, M. van der Bouma, J. Boehm, G. Goudoever, J.B. van Seuningen, I. van Renes, I.B. |
2009-06-01
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Combined defects in epithelial and immunoregulatory factors exacerbate the pathogenesis of inflammation: Mucin 2-interleukin 10-deficient mice
(Article)
Sluis, M. van der Bouma, J. Vincent, A. Velcich, A. Carraway, K.L. Büller, H.A. Einerhand, A.W.C. Goudoever, J.B. van Seuningen, I. van Renes, I.B. |
2008-06-24
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Forkhead box transcription factors Foxa1 and Foxa2 are important regulators of Muc2 mucin expression in intestinal epithelial cells
(Article)
Sluis, M. van der Vincent, A. Bouma, J. Male, A.K.V. Goudoever, J.B. van Renes, I.B. Seuningen, I. van |
2008-05-16
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Methotrexate-induced mucositis in mucin 2-deficient mice
(Article)
Koning, B.A.E. de Sluis, M. van der Lindenbergh-Kortleve, D.J. Velcich, A. Pieters, R. Büller, H.A. Einerhand, A.W.C. Renes, I.B. |
2007-01-01
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