Gent, D.C. van

protein recombination repair substrate cleavage activity artemi dna-pkc mutation patient reaction signal dna ends sequence figure rag 1 coding expression level product kinase result analysis strand damage integration dna-pk formation hairpin oligonucleotide assay wild-type dna-dependent protein kinase microrna cancer binding defect rag 2 proteins presence dna damage pathway autophosphorylation molecule control rag 1 protein mutant double-strand nucleotide nr 4a hmre 11 end-joining hiv -2 phosphorylation dsb repair number position targetscan ligation ligase cycle target experiment response replication deletion region van gent rag proteins ssdna break structure addition complex dna substrates fragment function fibroblast mre 11 dna repair brca 1