Gellert, M.

protein signal cleavage recombination rag 1 hairpin substrate coding reaction sequence rag 2 proteins rag 1 protein heptamer figure product rag proteins formation strand rag 2 23- signal hairpin formation 12- activity 23- position rag 2 protein flank nonamer coding ends 12- signal hmg 1 gellert cleavage reaction spacer oligonucleotide mutation binding van gent structure coding flank addition signal ends signal sequences expression nicking recombination signal sequences hmg 1 protein experiment cleavage products condition segment electrophoresis coding flank sequences plasmid phosphodiester bond recognition ramsden level molecule system extract factor species sadofsky result 12/23 rule fraction signal sequence hesse recombination signal effect presence buffer column figure 2 recombination signals element fragment figure 2 b repair