Peters, G.J.

hbm collection collection polymorphism patient folate study mthfr variant trial cancer eortc biomarker research leukemia assay folate-related genes reductase carrier blood sample folate status effect lymphoblastic leukemia hbm collection setup treatment protocol methylenetetrahydrofolate reductase allele synthase result analysis genotype group folate-related folate metabolism project design erasmus mc status number interaction lymphoblastic fluence correlative tr susceptibility childhood example metabolism development tr project european organization methylenetetrahydrofolate reductase gene thymidylate synthase correlative leukemia risk specimen tr study homocysteine thymidylate mechanism element adult erasmu factor european patient samples figure control quality cancer patients genet folate carrier methionine trial design sample size expertise folate-related genes blood j med genet checklist translational