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t-all notch mutation expression analysis leukemia notch 1 sample lymphoblastic leukemia tumor wt 1 mutations control dexamethasone cancer protein mef 2c lymphoblastic tlx 1 ptpn 2 mouse result figure table nature deletion il 7r mutations t-cell patient receptor number cluster glucocorticoid sequence sirna activation il -7r cutll 1 cells identi fied identi 2-1 phf 6 chromosomal treatment shrna phf 6 mutations level t-all cases survival oncogene study domain blood rearrangement volume il 7r right bcl 11b nkx 2-1 allele factor university cleavage 2 cleavage site inhibitor cutll wild-type effect alteration adult promoter ba /f cells il -7 t-all samples 1-induced array ptpn 2 expression mutant viability oncogenic genetic
8 Most Recent Publications
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Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia
(Article)
Zenatti, P.P. Ribeiro, D. Sarmento, L.M. Correia, N. Toribio, M.L. Kobarg, J. Horstmann, M. Pieters, R. Brandalise, S.R. Ferrando, A.A. Meijerink, J.P.P. Durum, S.K. Li, W. Yunes, J.A. Barata, J.T. Zuurbier, L. Silva, M.C. Paganin, M. Tritapoe, J. Hixon, J.A. Silveira, A.B. Cardoso, B.A. |
2011-10-01
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Integrated Transcript and Genome Analyses Reveal NKX2-1 and MEF2C as Potential Oncogenes in T Cell Acute Lymphoblastic Leukemia
(Article)
Homminga, I. Pieters, R. Vlierberghe, P. van Ferrando, A.A. Cayuela, J.M. Verhaaf, B. Beverloo, H.B. Horstmann, M. Haas, V. de Wiekmeijer, A.-S. Pike-Overzet, K. Staal, F.J.T. Langerak, A.W. Laat, W.L. de Soulier, J. Sigaux, F. Meijerink, J.P.P. Rooi, J.J. de Stubbs, A. Verstegen, M.M.A. Vuerhard, M.J. Buijs-Gladdines, J.G.C.A.M. Kooi, C. Klous, P. |
2011-04-12
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The TLX1 oncogene drives aneuploidy in T cell transformation
(Article)
Keersmaecker, K. de Real, P.J. Hadler, M. Lenz, J. Aplan, P.D. Kelliher, M. Kee, B.L. Pandolfi, P.P. Kappes, D. Gounari, F. Petrie, H. Meulen, J. van der Gatta, G.D. Speleman, F. Paietta, E. Racevskis, J. Wiernik, P.H. Rowe, J. Soulier, J. Avran, D. Cavé, H. Dastugue, N. Raimondi, S. Palomero, T. Meijerink, J.P.P. Cordon-Cardo, C. Califano, A. Ferrando, A.A. Sulis, M.L. Tosello, V. Vlierberghe, P. van Barnes, K. Castillo, M. Sole, X. |
2010-11-01
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Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia
(Article)
Kleppe, M. Lahortiga, I. Sigaux, F. Haferlach, T. Wlodarska, I. Vandenberghe, P. Soulier, J. Cools, J. El Chaar, T. Keersmaecker, K. de Mentens, N. Graux, C. Roosbroeck, K. van Ferrando, A.A. Langerak, A.W. Meijerink, J.P.P. |
2010-06-01
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PHF6 mutations in T-cell acute lymphoblastic leukemia
(Article)
Vlierberghe, P. van Palomero, T. Taghon, T. Zuurbier, L. Cauwelier, B. Harrison, C.J. Schwab, C. Pisecker, M. Strehl, S. Langerak, A.W. Gecz, J. Sonneveld, E. Khiabanian, H. Pieters, R. Paietta, E. Rowe, J. Wiernik, P.H. Benoit, Y. Soulier, J. Poppe, B. Yao, X. Cordon-Cardo, C. Meijerink, J.P.P. Meulen, J. van der Rabadan, R. Speleman, F. Ferrando, A.A. Castillo, M. Roy, N. van Moerloose, B. de Philippé, J. González-García, S. Toribio, M.L. |
2010-04-01
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WT1 mutations in T-ALL
(Article)
Tosello, V. Mansour, M.R. Real, P.J. Murty, V. Yao, X. Richards, S.M. Goldstone, A.P. Rowe, J. Basso, G. Wiernik, P.H. Paietta, E. Pieters, R. Barnes, K. Horstmann, M. Meijerink, J.P.P. Ferrando, A.A. Paganin, M. Sulis, M.L. Jenkinson, S. Allen, C.G. Gale, R.E. Linch, D.C. Palomero, T. |
2009-11-19
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γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia
(Article)
Real, P.J. Tosello, V. Meijerink, J.P.P. Aifantis, I. Basso, G. Cordon-Cardo, C. Ai, W. Ferrando, A.A. Palomero, T. Castillo, M. Hernando, E. Stanchina, E. de Sulis, M.L. Barnes, K. Sawai, C. Homminga, I. |
2009-01-01
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NOTCH1 extracellular juxtamembrane expansion mutations in T-ALL
(Article)
Sulis, M.L. Williams, O. Palomero, T. Tosello, V. Pallikuppam, S. Real, P.J. Barnes, K. Zuurbier, L. Meijerink, J.P.P. Ferrando, A.A. |
2008-08-01
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