Flotho, C.

mutation methylation patient leukemia myelomonocytic leukemia blood myelomonocytic sample cbl mutations protein university children syndrome myeloid analysis dna methylation cancer number department erasmus mc hypermethylation island prognostic table cpg island methylation .371y factor figure control calca growth cdkn 2b diagnosis subject germline volume expression identi fied cbl mutation erasmu hematopoietic relapse identi p .371y assay − − nature ptpn 11 m.l.l group pathway pediatrics jmml cases myelodysplastic syndromes ligase library colony study myeloid leukemia mouse disease childhood bone marrow noonan syndrome hospital value function germline cbl mutations article score signi splice model noonan prognostic value flotho san francisco jmml cells level myelodysplastic