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expression infant patient sample mll-rearranged mll-rearranged infant leukemia gene expression blood methylation study mutation group flt 3 figure flt 3 expression probe lymphoblastic leukemia translocation erasmus mc lymphoblastic prednisolone signi resistance signature children erasmu level probe sets ficantly dna methylation flt 3 mutations analysis prednisolone resistance cancer mll translocations microarray prednisone mll germline infant treatment number fusion den boer ml article pattern bone marrow samples patient groups library fication activation b-all precursor b-all 2011. signi ficantly precursor b-all samples precursor identi outcome response marrow myeloid leukemia protein volume result receptor mll translocation infant patients promoter domain germline island gene expression signatures subgroups speci cell lines myeloid hypermethylated kinase patient samples inhibitor
6 Most Recent Publications
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Gene expression profiling-based dissection of MLL translocated and MLL germline acute lymphoblastic leukemia in infants
(Article)
Stam, R.W. Schneider, P. Hagelstein, J. Linden, M.H. van der Stumpel, D.J.P.M. Menezes, R.X. de Lorenzo, P. de Valsecchi, M.G. Pieters, R. |
2010-04-08
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Association of high-level MCL-1 expression with in vitro and in vivo prednisone resistance in MLL-rearranged infant acute lymphoblastic leukemia
(Article)
Stam, R.W. Boer, M.L. den Pieters, R. Schneider, P. Boer, J.B. de Hagelstein, J. Valsecchi, M.G. Lorenzo, P. de Sallan, S.E. Brady, H.J.M. Armstrong, S.A. |
2010-02-04
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Specific promoter methylation identifies different subgroups of MLL-rearranged infant acute lymphoblastic leukemia, influences clinical outcome, and provides therapeutic options
(Article)
Stumpel, D.J.P.M. Schneider, P. Roon, E.H.J. van Boer, J.M. Lorenzo, P. de Valsecchi, M.G. Menezes, R.X. de Pieters, R. Stam, R.W. |
2009-12-24
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Role of mutation independent constitutive activation of FLT3 in juvenile myelomonocytic leukemia
(Article)
Vries, A.C. de Stam, R.W. Schneider, P. Niemeyer, C.M. Wering, E.R. van Haas, O.A. Kratz, C.P. Boer, M.L. den Pieters, R. Heuvel-Eibrink, M.M. van den |
2007-11-01
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D-HPLC analysis of the entire FLT3 gene in MLL rearranged and hyperdiploid acute lymphoblastic leukemia
(Article)
Stam, R.W. Boer, M.L. den Schneider, P. Meier, M. Beverloo, H.B. Pieters, R. |
2007-11-01
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Prognostic significance of high-level FLT3 expression in MLL-rearranged infant acute lymphoblastic leukemia [8]
(Article)
Stam, R.W. Schneider, P. Lorenzo, P. de Valsecchi, M.G. Boer, M.L. den Pieters, R. |
2007-10-01
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