Georget, V.

receptor protein mutation binding hormone wild-type expression endocrinol leydig cell hypoplasia library erasmus mc patient cells transfected surface lh receptor processing transfected leydig luteinizing hormone receptor luteinizing wild-type lhr lhr protein metab cell surface n-linked region processing glycoprotein hormone receptors psg 5-hlhr n-linked glycosyl groups psg 5-hlhrc codon 343 hypoplasia marten endoplasmic reticulum codon vector signal addition change cause result themmen 5-hlhr 80- erasmu ligand binding codon 543 sequence activity missense mutations absence analysis lutropin /choriogonadotropin receptor reticulum molecule 80- kda protein leydig cell differentiation glycosylated level fragment missense gonadotropin transfection phenotype transduction hlhrc endocrinology study cysteine endoplasmic exon 11 acid change november downloaded inactivating mutations mass forms library domain lhr gene missense mutation ligand