Cock, R.F.W. De

model covariate dataset dosing children population neonate concentration pharmacokinetic clearance postnatal age value study patient analysis pharmacokinetic model parameter postnatal paediatric regimen amikacin function distribution method birthweight evaluation information dosing regimens variability pharmacol ibuprofen maturation postmenstrual age sample body weight effect filtration rate pharmacokinet weight ctrough model-building datasets approach number covariate analysis estimate result modelling infant amikacin clearance adult parameter estimates term neonates preterm co-administration model-based dosing regimen influence dosing regimen change validation figure target model-building table range target ctrough values propofol filtration research population approach example postmenstrual volume ctrough values pharmacodynamic point knibbe bodyweight model-based right 100.0