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level study factor von willebrand factor willebrand patient blood vwf levels association disease thrombosis variation group janine 13-09-12 4.indd stxbp 5 plasma re flexivity effect vwf plasma levels polymorphism event stx 2 stxbp heart j thromb haemost abo blood group chapter allele platelet protein determinant thrombospondin adamt heart disease thromb individual maat mp blood group activity infarction flexivity risk factors cohort vwf molecules ischemic stroke relationship population leebeek fw stroke client type 1 vwd analysis subject haemost device alx -0081 ischemic organization vwf gene table leebeek -0081 addition concentration increase exercise region model participant control thrombospondin genes research meta-analysi variant molecule marker baseline aggregation