Salomons, G.S.

creatine idh 1r treatment mutation patient idh 1 glioma idh 1r cells effect tumor proliferation 87 cells idh 1wt idh 1 mutations analysis activity brain cell lines glycine -2-hg idh 2 mutations defect crtr defect month transporter increase result study creatine synthesis deficiency enzyme score l-arginine proliferation rate 87 cell lines information expression neuropsychological metab synthesis assessment 1 h-mrs glioma cell lines netherland idh 1r expression center department salomons gs neuropsychological assessments isocitrate salomon concentration cancer measurement idh 1 mutation creatine monohydrate grade creatine transporter defect presence braissant function subscale supplementation group vu university arginine iq scores migration pattern university idh 1bio metab dis pathway speech assay disorder genet x-linked survival intracranial injection myeloid leukemia