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study association longevity disease pathway analysis leiden research multimorbidity d-dimer effect cohort control diabetes genome-wide netherland university condition level rs 2075650 leiden 85- variant prevalence table population center registry rs 429358 factor replication genet hypertension rs gwas controls allele value 85- rotterdam study health heart telomere leiden longevity study erasmus mc grant protein locus rotterdam survival online-only data supplement lls gwas cases nursing result phenotype p value variation hospital gwas data institute coagulation leiden university snp ratio test danish insulin nature nonagenarian d-dimer levels serum apoe locus population-based combination danish 1905 cohort deelen christensen method westendorp setting sample snp analysis plink set-based test slagboom pe epidemiology
4 Most Recent Publications
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Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways
(Article)
Deelen, J. Uh, H.-W. Westendorp, R.G.J. Goeman, J.J. Slagboom, P.E. Houwing-Duistermaat, J.J. Beekman, M. Monajemi, R. Heemst, D. van Thijssen, P.E. Böhringer, S. Akker, E.B. van den de Craen, A.J.M. Rivadeneira Ramirez, F. Uitterlinden, A.G. |
2011-11-24
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Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited
(Article)
Deelen, J. Beekman, M. Akker, E.B. van den Passtoors, W.M. Tiemeier, H. Heemst, D. van de Craen, A.J.M. Rivadeneira Ramirez, F. Geus, E.J.C. de Perola, M. Ouderaa, F.J. van der Gunn, D.A. Uh, H.-W. Boomsma, D.I. Uitterlinden, A.G. Christensen, K. Tikka-Kleemola, P. Heijmans, B.T. Houwing-Duistermaat, J.J. Westendorp, R.G.J. Slagboom, P.E. Helmer, Q. Kuningas, M. Christiansen, L. Kremer, D. Breggen, R. van der Suchiman, H.E.D. Lakenberg, N. |
2011-08-01
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Genetic predictors of fibrin D-dimer levels in healthy adults
(Article)
Smith, N.L. Huffman, J.E. Bis, J.C. Wild, S.H. Rumley, A. Yang, Q. Uitterlinden, A.G. Stott, D.J. Davies, G. Carter, A.M. Thorand, B. Polašek, O. Strachan, D.P. McKnight, B. Campbell, H. Rudnicka, A.R. Chen, M.H. Buckley, B.M. Harris, S.E. Peters, A. Pulanic, D. Lumley, T. de Craen, A.J.M. Huang, J. Liewald, D.C. Gieger, C. Ford, I. Gow, A.J. Luciano, M. Porteous, D.J. Guo, X. Sattar, N. Tenesa, A. Cushman, M. Dehghan, A. Slagboom, P.E. Visscher, P.M. Spector, T.D. Illig, T. Rudan, I. Bovill, E.G. Wright, A.F. McArdle, W.L. Tofler, G.H. Hofman, A. Trompet, S. Westendorp, R.G.J. Starr, J.M. Grant, P.J. Karakas, M. Hastie, N.D. Psaty, B.M. Wilson, J.F. Lowe, G.D.O. O'Donnell, C.J. Witteman, J.C.M. Lopez, L.M. Jukema, J.W. Deary, I.J. Soranzo, N. Koenig, W. Hayward, C. Shin, S.Y. Baumert, J. Vitart, V. |
2011-04-18
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Setting and registry characteristics affect the prevalence and nature of multimorbidity in the elderly
(Article)
Schram, M.T. Frijters, D. Schellevis, F.G. Lisdonk, E.H. van de Ploemacher, J. de Craen, A.J.M. Waal, M.W. de Rooij, F.J.A. van Heeringa, J. Hofman, A. Deeg, D.J.H. |
2008-11-01
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