Grandia, L.

alternative drug alternative recommendation dose adjustment response concentration adjustment plasma pharmacogenetic gene –drug interaction allele –drug genotype interaction table number calculation check inr evidence gene –drug increase maintenance dose patient increase dose hla-b dose adjustments cyp 2d cyp 2c netherland vkorc report relevance level volume dose increase reference citalopram combination subject result sertraline olanzapine nsaid phenotype plasma concentration thrombotic events check loading dose serum concentration decreased-activity event 7–10 days clozapine titrate dose drug –drug interactions pharmacology inhibitor radboud university nijmegen factor efficacy maintenance study morphine —not tramadol — — — imipramine factor v leiden ugt 1a allele cyp 2c genotype oxycodone quetiapine drug events dose reduction 53 drugs aromatase inhibitor breast cancer reduction nortriptyline department — — *1/*3