Wijk, L. van

penicillamine patient treatment collagen finger scleroderma flexion penicillamine treatment sclerosis finger flexion study ratio effect improvement increase hydroxyproline month disease result chapter change collagen ratio serum morphea urine january course progression method raynaud influence biopsy table decrease period value skin collagen control esophagus lesion conclusion determination reaction skin biopsies metacarpophalangeal flexion arthritis protein dosage content administration figure function metacarpophalangeal excretion reduction measurement shoulder tissue distribution cases e examination introduction collagen diseases lancet laboratory deposit finding prognosis sclerodermie forearm count organ joint liver mouth loth day fever hoofdstuk agent measure