Lagresle-Peyrou, C.

expression vector b cells sffv.corag rag 1 expression lentiviral 1-/- t cells number therapy figure blood level spleen cells transplantation sffv.corag 1-treated mice spleen t-cell fl ow cytometry rag 1à/à mice ficiency transgene reconstitution rag 1 ucoe.corag animal transfer 1-treated flow cytometry analysis leukemia gene therapy transgene expression serum corag analysis cytometry correction 0.00 efs.corag patient immunode sequence wt cells b-cell c g 1 pike-overzet percentage rag 1à/à cells rag 1à/à phenotype transduced lymphoid organs immunode ficiency rearrangement antibody serum ig levels element chromatin opening element rag 1 sequence transduction protein t-cell reconstitution rag proteins transgene expression levels lentiviral vectors result activity codon-optimized segment virus lymphoid netherland codon lymphocytes hematopoietic sffv.rag rag 1à/à function ficient b-cell reconstitution vector copy