Zdzienicka, M.Z.

artemi mutation patient recombination repair dna-pkc protein m 3 cells broblast analysis fi broblasts defect end-joining fibroblast coding assay ficient number microhomology activity irradiation sensitivity artemis-de ficient cells rag 1 microhomology use rs-scid radiation aberration artemis gene mutations kinase wild-type formation cell cycle result ligase ficiency figure cell lines v 3 cells level control artemis-de sequence cycle artemis gene chromosomal dsb repair dna ligase iv signal expression immunode ficiency table checkpoint experiment immunol product pathway research radiosensitive chromosome van gent coding joints chromosomal aberrations precursor frequency dna-pk damage double-strand patient id 177 x-rays junction volume rs-scid patients dna double-strand blood immunode fragment stage artemis protein substrate