Wiegant, W.W.

artemi patient mutation dna-pkc repair m 3 cells recombination protein broblast defect analysis fi broblasts control number fibroblast ficient figure sensitivity activity irradiation artemis-de ficient cells coding aberration expression sequence level transcript cell cycle patient 2 ficiency b cells v 3 cells kinase radiation artemis-de rag 1 precursor b cells cycle chromosomal assay immunodeficiency precursor junction wild-type immunode ficiency patient 1 nucleotide checkpoint experiment research end-joining result wt artemis transcripts immunol chromosome artemis-deficient chromosomal aberrations van gent dsb repair scid h ijspeert frequency t cells damage scid patients x-rays granulomatous skin lesions formation patient id 177 table artemis gene coding joints radiosensitive immunode t lymphocytes dna-dependent protein kinase study stage exchange department blood